Transcriptomic analysis of cardiac remodelling following minimally invasive surgery for aortic regurgitation
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × S vs 4 × AR4 vs 4 × AR10 vs 4 × AR2Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A Novel Model of Cardiac Remodeling by a Minimally Invasive Aortic Regurgitation Surgery in MiceJACC. Basic to translational science · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE252164_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1057946 and SRA study SRP480370. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7995367 S1 S
- GSM7995368 S2 S
- GSM7995369 S3 S
- GSM7995370 S4 S
- GSM7995371 AR4-1 AR4
- GSM7995372 AR4-2 AR4
- GSM7995373 AR4-3 AR4
- GSM7995374 AR4-4 AR4
- GSM7995375 AR10-1 AR10
- GSM7995376 AR10-2 AR10
- GSM7995377 AR10-3 AR10
- GSM7995378 AR10-4 AR10
- GSM8634266 AR2-1 AR2
- GSM8634267 AR2-2 AR2
- GSM8634268 AR2-3 AR2
- GSM8634269 AR2-4 AR2
- GSE308914 Temporal Dynamics in Murine Cardiac Transcriptome following Myocardial Infarction 30 samples shares following, cardiac
- GSE218522 Gene expression following transverse aortic constriction in mice housed under normoxic or hypoxic conditions 24 samples shares following, aortic
- GSE303852 Liver RNA-seq from obese mice following Roux-en-Y gastric bypass or sham surgery under chow or high-fat diet conditions 20 samples shares following, surgery
- GSE285626 Potent Suppression of Heme-Induced Ferroptosis in Cardiomyocytes Enhances Cardiac Function Following Myocardial Infarction/Reperfusion Injury 18 samples shares following, cardiac
- GSE279588 Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice 16 samples shares remodelling, aortic
- GSE262065 A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery 10 samples shares following, surgery
- GSE211550 Macrophages adopt mural cell function and marker expression for vascular support following ischemia 1509 samples shares following
- GSE297702 Light and sex modify Snord116 genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment 219 samples shares following
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.