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METTL3 deficiency aggravates hepatic ischemia/reperfusion injury in mice by activating the MAPK signaling pathway

GSE252255 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/04/22 Platform GPL24247
Summary
Inflammatory responses, apoptosis, and oxidative stress, are key factors that contribute to hepatic ischemia/reperfusion (I/R) injury, which may lead to the failure of liver surgeries, such as hepatectomy and liver transplantation. The N6-methyladenosine (m6A) modification has been implicated in multiple biological processes, and its specific role and mechanism in hepatic I/R injury require further investigation. We found that METTL3 may be involved in regulating this process. Therefore, we constructed an ischemia-reperfusion model with Hepatocyte-specific METTL3 knockdown (HKD) mice, and performed RNA- sequencing analysis with wild-type mice as controls.
Published in
METTL3 Deficiency Aggravates Hepatic Ischemia/Reperfusion Injury in Mice by Activating the MAPK Signaling Pathway
Gao Y, Wang M, Qin R et al. · International journal of medical sciences 2024 · PMID 38774758 · doi:10.7150/ijms.94177
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Also filed as BioProject PRJNA1059018 and SRA study SRP480648. Searching any of these in the dataset finder brings you back here.

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