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Multilineage origins of lymphatic muscle cells with transcriptional parallels to venous smooth muscle

GSE252376 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/06/30 Platform GPL30172
Summary
Lymphatic muscle cells (LMCs) have distinct contractility compared to vascular smooth muscle cells covering blood vessels (SMCs). Additionally, we found LMC and SMC populations to be partially derived from WT1-expressing progenitors. To learn more about the potential differences between WT1-derived cells and their counterparts, as well as the potential differences between LMCs and SMCs, we performed scRNAseq on popliteal lymphatics and veins of WT1 reporter mice.
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Direct links to NCBI, no account and no request form: the whole study as GSE252376_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1060308 and SRA study SRP480977. Searching any of these in the dataset finder brings you back here.

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