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Tgfβ signaling hyperactivates glycolysis via positive feedback to promote interzone formation and joint tissue development

GSE252486 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/31 Platform GPL24247
Summary
The role of bioenergetics in synovial joint development is unknown. With single-cell RNA sequencing (scRNA-seq) in the knee joint primordia, we discover that the Gdf5-expressing interzone cells are enriched for the expression of glycolysis genes.
Published in
Tgfβ signaling stimulates glycolysis to promote the genesis of synovial joint interzone in developing mouse embryonic limbs
Song C, Sawall JK, Ji X et al. · Science advances 2025 · PMID 39772668 · doi:10.1126/sciadv.adq4991
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Also filed as BioProject PRJNA1060716 and SRA study SRP481167. Searching any of these in the dataset finder brings you back here.

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