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Bulk-RNA sequencing of E8.25 posterior tissue +2 somites from controls and Sp5/8 double knockout or Wnt3a knockout embryos

GSE252659 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/11/12 Platform GPL13112
Summary
Sp5/8 are Zn finger downstream transcription factors of Wnt/b-catenin signaling pathway. Deletion of Sp5/8 in mice result in severer posterior axis truncation by E9.5 closely resembling Wnt pathway mutants. The goal of this project is to identify differentially expressed genes between controls and Sp5/8 double knockout mutants that could potentially reveal mechanisms of the role of Sp5/8 factors in self-renewal and differentiation of caudal progenitors.
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Also filed as BioProject PRJNA1061580 and SRA study SRP482178. Searching any of these in the dataset finder brings you back here.

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