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Effect of CAR-M2 hydrogel treatment on the expression of related genes such as fibrosis and endothelial angiogenesis in mice with renal fibrosis

GSE252943 Mus musculus Expression profiling by high throughput sequencing 3 samples Submitted 2026/02/06 Platform GPL24247
Summary
Kidney fibrosis involves the dynamic interactions of various cells, including immune cells, stromal cells, and ECs. Macrophages regulate regeneration and fibrosis through the interaction with other cell types, inducing some effects including the clearance of apoptotic myofibroblasts. Moreover, M2 macrophages promote tissue angiogenesis and participate in the reparative processes of soft tissue remodeling. Therefore, in addition to the direct effect of macrophage on renal fibrosis, its indirect regulatory role is also worthy to be explored. Its interaction with activated fibroblasts and ECs in renal fibrosis is unknown. Here our data discovered the heterogenicity and interaction of stroma and EC. Moreover, the infiltration of Cxcr2+ EC and expression of Lcn2 were indentfied highly related renal fibrosis. Taken together, our data provide a deeper understanding of the expression profile of renal fibrosis in mice, provide novel molecular targets for the treatment of renal fibrosis.
Published in
CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2(+) endothelial cells
Zhao W, Zhou X, Zhao X et al. · Cell reports. Medicine 2026 · PMID 41887221 · doi:10.1016/j.xcrm.2026.102698
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Also filed as BioProject PRJNA1063288 and SRA study SRP482920. Searching any of these in the dataset finder brings you back here.

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