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Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development

GSE253901 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/09 Platform GPL24247
Summary
Thymic atrophy is the initial event of immune aging and leads to developmental disorders of T cell . Invariant natural killer T (iNKT) cells are a distinctive subset of innate-like T cells, which are involved in the occurrence and development of various diseases, such as tumor, obesity and diabetes. Cell therapy targeting iNKT cells has become an emerging therapy after PD-1/PD-L1, CTLA-4 and CAR-T therapy. However, the scarcity of iNKT cells in the body limits its application in clinical therapy. A large number of clinical studies and preclinical studies have demonstrated that Ganoderma lucidum spores (GLS) regulates traditional T cell development. Nevertheless, whether GLS regulates iNKT cell development and its underlying mechanisms remains unknown.
Published in
Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development
Yang J, Pan H, Wang M et al. · Frontiers in pharmacology 2024 · PMID 39221140 · doi:10.3389/fphar.2024.1419881
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Also filed as BioProject PRJNA1067641 and SRA study SRP485277. Searching any of these in the dataset finder brings you back here.

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