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Cranial Photomodulation Reshapes Brain Border Immunity and Promotes Recovery After Stroke

GSE254550 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2024/04/18 Platform GPL24247
Summary
The skull bone marrow represents a targetable neuroimmune interface adjacent to the brain borders with the potential to improve stroke outcomes. Here, we identified the skull as a highly responsive immune niche and developed a cranial photo-immunologic regulation (CPR) strategy using low-dose, narrow-band medical UVB. Targeted irradiation of the interparietal region reshapes brain border immune crosstalk, effectively promoting repair and functional recovery after ischemic injury. Mechanistically, UVB-based CPR reverses stroke-induced suppression of meningeal B cell activation, contributing to restoring brain border immune homeostasis. Depletion of meningeal B cells further demonstrates that these cells are required for the therapeutic effects of CPR. These findings establish the skull as an actionable target for neuroimmune modulation along the skull–meninges–brain axis and provide a potentially transformative strategy for treating neurological disease.
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Direct links to NCBI, no account and no request form: the whole study as GSE254550_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1071029 and SRA study SRP486820. Searching any of these in the dataset finder brings you back here.

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