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Role of the catalytic beta subunit of calcineurin (Ppp3cb) in angiotensin II induced vascular changes

GSE255932 Mus musculus (mouse) RNA-seq (gene expression) 24 samples Submitted 2026/06/30 Platform GPL13112
At a glance

RNA-seq (gene expression) · mouse · 24 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Summary (written by the submitters)
Cardiovascular diseases are common causes of death and often coincide with vascular remodeling induced by pathological activation of the renin-angiotensin-aldosterone system (RAAS). angiotensin II (angII), a key effector of the RAAS, is an important mediator of pathological vascular changes by contributing to altered vascular tone, inflammatory processes and structural remodeling with fibrosis.
Read the full summary ↓
Several studies showed sex differences in the cardiovascular angII response. Calcineurin (PPP3), a serine/threonine phosphatase consisting of an enzymatic and a catalytic subunit, is known for its role in inflammatory processes and cellular hypertrophy. Hence, we investigated the role of calcineurin for angII-induced vascular remodeling with the help of a mouse model lacking the catalytic beta subunit of calcineurin (Ppp3cb KO).
This dataset
Open GSE255932 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255932_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1077269 and SRA study SRP489991. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Study design
8 conditions, mostly in triplicate
aorta, control, WT, female, ×3 aorta, angiotensinII, WT, female, ×3 aorta, control, KO, female, ×3 aorta, angiotensinII, KO, female, ×3 aorta, control, WT, male, ×3 aorta, angiotensinII, WT, male, ×3 aorta, control, KO, male, ×3 aorta, angiotensinII, KO, male, ×3

Supports a between-group comparison across 24 samples.

How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.