Joint transcriptional disruption of Ret and Ednrb drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease
RNA-seq (gene expression) · mouse · 64 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 64 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Joint disruption of Ret and Ednrb transcription shifts cell fate trajectories in the enteric nervous system in Hirschsprung diseaseProceedings of the National Academy of Sciences of the United States of America · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255964_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1077307 and SRA study SRP490037. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 60 samples.
How we read this: 6 replicated groups read from 64 sample titles; they account for 60 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7103062 E145_1 E145
- GSM7103063 E145_10 E145
- GSM7103064 E145_100 E145
- GSM7103065 E145_105 E145
- GSM7103066 E145_106 E145
- GSM7103067 E145_11 E145
- GSM7103068 E145_12 E145
- GSM7103069 E145_14 E145
- GSM7103070 E145_15 E145
- GSM7103071 E145_16 E145
- GSM7103072 E145_17 E145
- GSM7103073 E145_18 E145
- GSM7103074 E145_2 E145
- GSM7103075 E145_3 E145
- GSM7103076 E145_4 E145
- GSM7103077 E145_5 E145
- GSM7103078 E145_51 E145
- GSM7103079 E145_7 E145
- GSM7103080 E145_8 E145
- GSM7103081 E145_85 E145
- GSM7103082 E145_93 E145
- GSM7103083 E145_96 E145
- GSM7103084 E145_98 E145
- GSM7103085 E145_99 E145
- GSM7103086 P0_1 P0
- GSM7103087 P0_10 P0
- GSM7103088 P0_12 P0
- GSM7103089 P0_14 P0
- GSM7103090 P0_15 P0
- GSM7103091 P0_16 P0
- GSM7103092 P0_17 P0
- GSM7103093 P0_19 P0
- GSM7103094 P0_2 P0
- GSM7103095 P0_25 P0
- GSM7103096 P0_27 P0
- GSM7103097 P0_28 P0
- GSM7103098 P0_29 P0
- GSM7103099 P0_30 P0
- GSM7103100 P0_5 P0
- GSM7103101 P0_7 P0
+ 24 more — browse all 64 samples with per-sample file links →
- GSE227574 Joint transcriptional disruption of Ret and Ednrb drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease [bulkRNA-seq] 54 samples shares hirschsprung, disruption, reversal, enteric, nervous, drives, system, joint
- GSE302208 Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation [Neuron SmartSeq2] 169 samples shares enteric, nervous, system
- GSE263945 Inflammation Rewires the Enteric Nervous System Through Neurogenic Monocyte Recruitment 33 samples shares enteric, nervous, system
- GSE275794 Tachykinin signaling defines distinct populations of glia in the enteric nervous system [Bulk RNA-seq] 19 samples shares enteric, nervous, system
- GSE301963 Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation [10xGermfree] 16 samples shares enteric, nervous, system
- GSE308383 Single nucleus tanscriptomic analysis of the mouse enteric nervous system 15 samples shares enteric, nervous, system
- GSE302051 Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation [10xPerturbSeq] 14 samples shares enteric, nervous, system
- GSE268241 HPV16-expressing tumors release multiple IL-1 ligands to orchestrate systemic immunosuppression whose disruption enables efficacy of a therapeutic vaccine. 63 samples shares disruption, system
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.