Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 20 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Class IIa HDACs forced degradation allows resensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancerMolecular oncology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE256187_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1078385 and SRA study SRP490512. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8087300 H3K27ac WT SICT UNT
- GSM8087301 H3K27ac WT SICT OXPT
- GSM8087302 H3K27ac WT SIHDAC4 UNT
- GSM8087303 H3K27ac WT SIHDAC4 OXPT
- GSM8087304 H3K27ac FBXW7 KO SICT UNT
- GSM8087305 H3K27ac FBXW7 KO SICT OXPT
- GSM8087306 H3K27ac FBXW7 KO SIHDAC4 UNT
- GSM8087307 H3K27ac FBXW7 KO SIHDAC4 OXPT
- GSM8087308 Input WT
- GSM8087309 Input FBXW7 KO
- GSM8087310 H3K27ac WT SICT UNT B
- GSM8087311 H3K27ac WT SICT OXPT B
- GSM8087312 H3K27ac WT SIHDAC4 UNT B
- GSM8087313 H3K27ac WT SIHDAC4 OXPT B
- GSM8087314 H3K27ac FBXW7 KO SICT UNT B
- GSM8087315 H3K27ac FBXW7 KO SICT OXPT B
- GSM8087316 H3K27ac FBXW7 KO SIHDAC4 UNT B
- GSM8087317 H3K27ac FBXW7 KO SIHDAC4 OXPT B
- GSM8087318 Input WT B
- GSM8087319 Input FBXW7 KO B
- GSE270840 Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer 10 samples shares oxaliplatin-resistant, re-sensitization, super-enhancers, reorganization, fbxw7-mutated, colorectal, controls
- GSE256188 Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer 36 samples shares oxaliplatin-resistant, re-sensitization, super-enhancers, reorganization, fbxw7-mutated, colorectal, controls
- GSE301368 Acute hormonal signaling-induced 3D chromatin loop reorganization controls adipocyte thermogenesis [ChIP-seq human] 10 samples shares reorganization, controls, chip-seq
- GSE207822 Chromatin reorganization drives expression of functional maturation genes in senescent pancreatic beta cells (Series3 - Chromatin profiles, ChIP-seq) 40 samples shares reorganization, chip-seq
- GSE171804 SUMOylation Regulates Super-Enhancers Through Transcription Factor TFAP2C Binding on Chromatin [ChIP-seq] 22 samples shares super-enhancers, chip-seq
- GSE53998 NF-kB coordinates rapid, BRD4-dependent remodeling of proinflammatory super-enhancers [ChIP-Seq] 21 samples shares super-enhancers, chip-seq
- GSE292716 Super-enhancers-driven SOX4/SMAD3 enhances AXL signaling via membrane phospholipid remodeling to accelerate leukemia progression [ChIP-seq] 20 samples shares super-enhancers, chip-seq
- GSE251672 Transcription factor reorganization at chromatin secures myeloid progenitor cell survival in PU.1 downregulated leukemia [ChIP-seq] 20 samples shares reorganization, chip-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.