GEO series

Transcriptome Analysis of Kidneys in a Mouse Model of Sepsis-Induced Acute Kidney Injury

GSE256430 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/23 Platform GPL24247

Summary

This study delves into the pathophysiological underpinnings of sepsis-associated acute kidney injury (SA-AKI), a critical and often fatal complication arising from the systemic inflammatory response and immune dysregulation triggered by sepsis. By employing the cecal ligation and puncture (CLP) method to simulate sepsis-induced AKI in mice, we conducted comprehensive transcriptome profiling using RNA sequencing (RNA-seq) to explore the molecular dynamics and identify potential new mechanisms underlying SA-AKI. The comparative analysis between the CLP-induced AKI model and control subjects aims to unravel the complex interplay of genes and signaling pathways involved in kidney damage and failure during sepsis. Through this approach, our research seeks to contribute to the broader understanding of SA-AKI's molecular basis.

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Direct links to NCBI, no account and no request form: the whole study as GSE256430_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1079657 and SRA study SRP491315. Searching any of these in the dataset finder brings you back here.

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