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Loss of GRB2 results in nonreceptive endometrium and female infertility.

GSE260505 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/01/07 Platform GPL24247
Summary
To understand the role of GRB2 in the uterus, we generated mice with conditional ablation of Grb2 in the PGR positive cells (Pgrcre/+Grb2f/f; Grb2d/d). Grb2d/d mice are infertile due to implantation failure. Although ovarian functions are normal, Grb2d/d mice had non-receptive endometrium due to dysregulation of progesterone and estrogen signaling. Our transcriptomic analysis identified deficiency of progesterone and FOXA2 signaling.
Published in
GRB2 regulation of essential signaling pathways in the endometrium is critical for implantation and decidualization
Tran DN, Hwang YJ, Kim KC et al. · Nature communications 2025 · PMID 40038241 · doi:10.1038/s41467-025-57173-2
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Also filed as BioProject PRJNA1081904 and SRA study SRP492397. Searching any of these in the dataset finder brings you back here.

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