GEO series
Chronic BCR signaling generates and maintains age-associated B cells from anergic B cell
GSE260576
Mus musculus
Expression profiling by high throughput sequencing
15 samples
2025/04/23
GPL24247
Summary
We report here that ABCs exhibited a unique phenotype in aging and lupus model mice, where BCR signaling is constitutively activated, and surface BCRs are internalized. Autoreactive anergic B cells exclusively differentiated into ABCs in a BCR-dependent manner in vivo. Additionally, anergic B cells showed enhanced ABC differentiation in vitro compared to naive B cells. This was suppressed by Nr4a1 expression, possibly due to the inhibition of several signaling pathways, including BCR.
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Paper (PMID 40249819) ↗
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