GEO series
A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia
GSE261198
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/06/03
GPL21103
Summary
To elucidate the role of STAT3β in acute myeloid leukemia (AML), we established a mouse model of STAT3β-deficient, MLL-AF9-driven AML. STAT3β-deficiency significantly shortened survival of leukemic mice confirming its role as a tumor suppressor. Furthermore, RNA sequencing revealed enhanced STAT1 expression and interferon (IFN) signaling upon loss of STAT3β.
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Paper (PMID 38806478) ↗
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