GEO series
The effect of RVG-SCMH1-Evs treatment on photothrombotic (PT) stroke mice
GSE261613
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/05/26
GPL24247
Summary
Metabolic dysfunction is considered a key event after ischemic stroke. However, the underlying mechanisms of metabolic disorders in cerebral ischemia is unknown. Circular RNA SCMH1 (circSCMH1), a circular RNA that has been reported to function in brain repair after stroke, was confirmed to be involved in metabolic disorders. circSCMH1 was delivered by rabies virus glycoprotein (RVG)-modified sxtracellular vesicle. Mechanistically, circSCMH1 decreased kynurenine 3-monooxygenase (KMO) expression, a key enzyme in kynurenine metabolism. Our findings suggested that circSCMH1 inhibited KMO expression, providing insight into the mechanism by which circSCMH1 promotes stroke recovery.
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Paper (PMID 39659575) ↗
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