Deletion of the X chromosome gene Kdm6a in microglia is protective in the multiple sclerosis model, female and male II
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 × Ctrl_EAE vs 6 × Ctrl_Healthy vs 6 × Met_EAEGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Deletion of the X-chromosomal gene Kdm6a in microglia of female mice ameliorates neuroinflammation and restores translatome profilesScience translational medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE261726_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1088497 and SRA study SRP495497. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 3 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8149677 Ctrl_EAE_1 Ctrl_EAE
- GSM8149678 Ctrl_EAE_10 Ctrl_EAE
- GSM8149679 Ctrl_EAE_17 Ctrl_EAE
- GSM8149680 Ctrl_EAE_18 Ctrl_EAE
- GSM8149681 Ctrl_EAE_2 Ctrl_EAE
- GSM8149682 Ctrl_EAE_9 Ctrl_EAE
- GSM8149683 Ctrl_Healthy_11 Ctrl_Healthy
- GSM8149684 Ctrl_Healthy_12 Ctrl_Healthy
- GSM8149685 Ctrl_Healthy_19 Ctrl_Healthy
- GSM8149686 Ctrl_Healthy_20 Ctrl_Healthy
- GSM8149687 Ctrl_Healthy_3 Ctrl_Healthy
- GSM8149688 Ctrl_Healthy_4 Ctrl_Healthy
- GSM8149689 Met_EAE_13 Met_EAE
- GSM8149690 Met_EAE_14 Met_EAE
- GSM8149691 Met_EAE_21 Met_EAE
- GSM8149692 Met_EAE_22 Met_EAE
- GSM8149693 Met_EAE_5 Met_EAE
- GSM8149694 Met_EAE_6 Met_EAE
- GSE296797 CD38+CD93+ microglia and macrophages drive neuroinflammation through glycolysis-histone lactylation axis in multiple sclerosis model mice 17 samples shares microglia, sclerosis, multiple
- GSE273690 Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease 48 samples shares protective, microglia
- GSE200461 The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice 30 samples shares chromosome, female
- GSE256287 Sirtuin 7 regulates dosage compensation and safeguards the female X-chromosome 182 samples shares chromosome, female
- GSE237390 Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3 [ChIP-seq] 54 samples shares kdm6a
- GSE264105 Plate-based scRNA-seq of plasma-positive microglia and plasma-negative microglia in young mice 1111 samples shares microglia
- GSE294851 Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [ChIP-seq] 17 samples shares kdm6a
- GSE279279 KDM6A facilitates Xist upregulation at the onset of X inactivation [CUT&Run] 14 samples shares kdm6a
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.