2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × WT vs 4 × KO vs 4 × AKO vs 4 × BKOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunctionNature metabolism · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271207_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1130460 and SRA study SRP517286. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8371748 WT1 WT
- GSM8371749 WT2 WT
- GSM8371750 WT3 WT
- GSM8371751 WT4 WT
- GSM8371752 KO1 KO
- GSM8371753 KO2 KO
- GSM8371754 KO3 KO
- GSM8371755 KO4 KO
- GSM8371756 AKO1 AKO
- GSM8371757 AKO2 AKO
- GSM8371758 AKO3 AKO
- GSM8371759 AKO4 AKO
- GSM8371760 BKO1 BKO
- GSM8371761 BKO2 BKO
- GSM8371762 BKO3 BKO
- GSM8371763 BKO4 BKO
- GSE326291 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [RNA-seq} 36 samples shares 2-hydroxyglutarate, mitochondrial
- GSE280273 A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F0_Liv_eWAT_RNAseq] 36 samples shares mitochondrial, dysfunction
- GSE293219 Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. 36 samples shares mitochondrial, dysfunction
- GSE300519 Neurotoxicity, α-Synuclein Pathology, and Mitochondrial Dysfunction: A Comparative Study of Three Parkinson’s Disease Mouse Models 35 samples shares mitochondrial, dysfunction
- GSE261940 Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis 20 samples shares mitochondrial, dysfunction
- GSE284451 Ceramides Drive Mitochondrial Dysfunction and Tubular Injury in AKI 16 samples shares mitochondrial, dysfunction
- GSE241176 Fibroblast-specific TGF-b signaling mediates dysfunction, fibrosis and hypertrophy in a mouse model of obesity-associated type 2 diabetes [RNA-seq: Smad3 in dbdb] 12 samples shares dysfunction, mediates
- GSE304446 Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF 12 samples shares mitochondrial, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.