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Bortezomib increases immunotherapy efficacy through enhancement of STING and IFN-γ signaling in lung adenocarcinoma

GSE262305 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/23 Platform GPL24247
Summary
BTZ has been reported to block cell proliferation and promote apoptosis of NSCLC cells. However, the clinical trails of BTZ alnoe or BTZ combinated with other chemotherapy have failed. Here, we reported that BTZ enhanced the anti-tumor efficacy of PD1/PDL1 blockade therapy in a Lewis lung carcinoma (LLC) tumor model. In both in vitro and in vivo assay, our data showed that BTZ activated STING pathway and increased the responsiveness of tumor cells to IFN-γ through the upregulation of surface IFN-γ receptor I (IFNGR1), which contributed to the superior anti-tumor efficacy of BTZ in combination with PD1/PDL1 inhibitors in lung adenocarcinoma.
Published in
Proteasome inhibition by bortezomib augments the efficacy of anti-PD-L1 therapy against lung cancer
Xi Y, Meng K, Yu T et al. · European journal of pharmacology 2026 · PMID 41740783 · doi:10.1016/j.ejphar.2026.178677
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Also filed as BioProject PRJNA1091193 and SRA study SRP497413. Searching any of these in the dataset finder brings you back here.

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