ATV-TfR and ATV-CD98hc biodistribution in the mouse brain
Single-cell RNA-seq · mouse · 23 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 23 samples: 23 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistributionNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE262436_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1091717 and SRA study SRP497770. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 23 sample titles: 23 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8169669 CD98hc_1_negative
- GSM8169670 CD98hc_1_low
- GSM8169671 CD98hc_1_medium
- GSM8169672 CD98hc_1_high
- GSM8169673 CD98hc_2_negative
- GSM8169674 CD98hc_2_low
- GSM8169675 CD98hc_2_medium
- GSM8169676 CD98hc_2_high
- GSM8169677 IgG_1_low
- GSM8169678 IgG_1_medium
- GSM8169679 IgG_1_high
- GSM8169680 IgG_2_negative
- GSM8169681 IgG_2_low
- GSM8169682 IgG_2_medium
- GSM8169683 IgG_2_high
- GSM8169684 TfR_1_ negative
- GSM8169685 TfR_1_ low
- GSM8169686 TfR_1_ medium
- GSM8169687 TfR_1_ high
- GSM8169688 TfR_2_negative
- GSM8169689 TfR_2_low
- GSM8169690 TfR_2_medium
- GSM8169691 TfR_2_high
- GSE98816 Single cell RNA-seq of mouse brain vascular transcriptomes 3186 samples shares brain
- GSE311449 Single cell RNA-seq of mouse brain vascular cells with Smart-seq2 method 391 samples shares brain
- GSE284504 Transcriptional profiling of brain from a zQ175 KI mouse model of Huntington's disease 335 samples shares brain
- GSE326452 Bulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling 200 samples shares brain
- GSE341480 Spatiotemporal Clonal Architecture of the Newborn Mouse Forebrain 186 samples shares brain
- GSE285890 Sex and genotype affect mouse hippocampal gene expression in response to blast-induced traumatic brain injury 96 samples shares brain
- GSE300113 Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer’s, CADASIL, and Traumatic Brain Injury (Main dataset) 59 samples shares brain
- GSE233811 Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia [bulk RNA-Seq] 48 samples shares brain
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.