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Effect of the depletion of YAP1 in adult spinal cord neural stem cells

GSE274111 Mus musculus Expression profiling by high throughput sequencing 20 samples 2026/08/06 GPL28330
Summary
Mouse spinal cord neural stem cells are know to be multipotent in vitro but mainly produce astrocytes in vivo. RNA sequencing and proteomic analysis showed that neural stem cells downregulate the Hippo/YAP1 pathway during OPC formation. To understand the implication of YAP1 in the oligodendrogliogenesis, we used transgenic cells expressing a truncated form of YAP1 and analyzed their mRNA expression in proliferation and differentiation
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