CNOT3 maintains ILC2 integrity by destabilizing Tbx21 and Rorc mRNAs [RNA-seq]
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CNOT3 supports ILC2 differentiation and function by destabilizing Tbx21 and Rorc transcriptsThe Journal of experimental medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263342_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1096737 and SRA study SRP500024. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8189896 NK_control_1 NK_control
- GSM8189897 NK_control_2 NK_control
- GSM8189898 NK_control_3 NK_control
- GSM8189899 NK_Cnot3CKO_1 NK_Cnot3CKO
- GSM8189900 NK_Cnot3CKO_2 NK_Cnot3CKO
- GSM8189901 NK_Cnot3CKO_3 NK_Cnot3CKO
- GSM8189902 LungILC2_control_1 LungILC2_control
- GSM8189903 LungILC2_control_2 LungILC2_control
- GSM8189904 LungILC2_control_3 LungILC2_control
- GSM8189905 LungILC2_Cnot3CKO_1 LungILC2_Cnot3CKO
- GSM8189906 LungILC2_Cnot3CKO_2 LungILC2_Cnot3CKO
- GSM8189907 LungILC2_Cnot3CKO_3 LungILC2_Cnot3CKO
- GSM8189908 SIILC2_control_1 SIILC2_control
- GSM8189909 SIILC2_control_2 SIILC2_control
- GSM8189910 SIILC2_control_3 SIILC2_control
- GSM8189911 SIILC2_Cnot3CKO_1 SIILC2_Cnot3CKO
- GSM8189912 SIILC2_Cnot3CKO_2 SIILC2_Cnot3CKO
- GSM8189913 SIILC2_Cnot3CKO_3 SIILC2_Cnot3CKO
- GSM8189914 SIILC3_control_1 SIILC3_control
- GSM8189915 SIILC3_control_2 SIILC3_control
- GSM8189916 SIILC3_control_3 SIILC3_control
- GSM8189917 SIILC3_Cnot3CKO_1 SIILC3_Cnot3CKO
- GSM8189918 SIILC3_Cnot3CKO_2 SIILC3_Cnot3CKO
- GSM8189919 SIILC3_Cnot3CKO_3 SIILC3_Cnot3CKO
- GSE326762 Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression - RNA-Seq 35 samples shares ilc2, rna-seq
- GSE230597 Bulk RNA-seq of ILC2, Tconv, Th2, Treg Gata3hi and Treg Gatalo from the lungs of IL-33 treated mice 22 samples shares ilc2, rna-seq
- GSE253293 Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [Bulk RNA-seq] 16 samples shares ilc2, rna-seq
- GSE272723 PAC1 constrains type II inflammation through promotion of CGRP signaling in ILC2s [RNA-seq] 16 samples shares ilc2, rna-seq
- GSE301976 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2] 12 samples shares ilc2, rna-seq
- GSE248386 ILC2 regulate a Pi16+ fibroblast progenitor niche in the pancreas (acute pancreatitis scRNA-seq) 10 samples shares ilc2, rna-seq
- GSE248383 ILC2 regulate a Pi16+ fibroblast progenitor niche in the pancreas (coculture bulk RNA-seq) 10 samples shares ilc2, rna-seq
- GSE73272 RNA-Seq analysis of mouse group 2 innate lymphoid cells (ILC2s) cultured with IL-33, IFN-g, and IL-27 9 samples shares ilc2, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.