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Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling

GSE263907 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/31 Platform GPL30215
Summary
To investigate skin aging is an important driver of experimental osteoarthritis(OA) progression in mice via enhanced IL-36 receptor (IL-36R) signaling. we generated epidermis keratinocyte conditional knockout mice (IL-36Ra-cKO) with topical administration of capsid-mutant Adeno-associated virus 2 (AAV2) vector23 encoding Cre recombinase (AAV2-Cre) to IL-36Rafl/fl mice. Subsequently, epidermal skin tissues were collected from IL-36Rafl/fl and IL-36Ra-cKO mice for RNA sequencing analysis.
Published in
Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling
Chen D, Wang C, Yang C et al. · Nature communications 2026 · PMID 41530151 · doi:10.1038/s41467-026-68399-z
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Also filed as BioProject PRJNA1099896 and SRA study SRP501604. Searching any of these in the dataset finder brings you back here.

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