Remodeling p38 signaling in muscle controls locomotor activity via IL-15
RNA-seq (gene expression) · mouse · 9 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples: 3 × gastrocnemius, COW vs 3 × gastrocnemius, HN vs 3 × gastrocnemius, KICGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Remodeling p38 signaling in muscle controls locomotor activity via IL-15Science advances · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE263912_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1099905 and SRA study SRP501614. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 9 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8207428 gastrocnemius, COW_1 gastrocnemius, COW
- GSM8207429 gastrocnemius, COW_2 gastrocnemius, COW
- GSM8207430 gastrocnemius, COW_3 gastrocnemius, COW
- GSM8207431 gastrocnemius, HN_1 gastrocnemius, HN
- GSM8207432 gastrocnemius, HN_2 gastrocnemius, HN
- GSM8207433 gastrocnemius, HN_3 gastrocnemius, HN
- GSM8207434 gastrocnemius, KIC_1 gastrocnemius, KIC
- GSM8207435 gastrocnemius, KIC_2 gastrocnemius, KIC
- GSM8207436 gastrocnemius, KIC_3 gastrocnemius, KIC
- GSE325919 Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans 30 samples shares remodeling, muscle
- GSE271650 Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes [bulk RNA-seq] 18 samples shares remodeling, controls
- GSE310620 RNA-seq in aortic smooth muscle cells from a mice lacking Arg1 expression in erytrhrocytes (RBC.ARG1-KO) and their litter mate controls (RBC.ARG1-WT) after culture in standard DMEM or foam cell medium (DIAM) 16 samples shares controls, muscle
- GSE336280 Murine pancreatic tumors induce pathological remodeling of muscles critical to chewing and swallowing [RNA-seq] 13 samples shares remodeling, muscle
- GSE275142 The Fosl1-Kdm6b Axis Controls Skeletal Muscle Fibrosis by Regulating Histone H3K27me3 [Cut&Tag] 24 samples shares controls, muscle
- GSE275143 The Fosl1-Kdm6b Axis Controls Skeletal Muscle Fibrosis by Regulating Histone H3K27me3 [HiCAR] 12 samples shares controls, muscle
- GSE252628 Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling 56 samples shares remodeling
- GSE291382 Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling 24 samples shares controls
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.