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IRG1 Promotes Neutrophil Reverse Migration and Alleviates Local Inflammation

GSE263953 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/14 Platform GPL19057
Summary
Polymorphonuclear neutrophil (PMN) infiltration at inflammatory site plays a critical role in inflammation. PMN reverse migration (rM) describes the phenomenon that PMNs migrate away from inflammatory site back into the vasculature, and its role within inflammatory scenarios remains to be fully determined. This study aimed to investigate the mechanism underlying PMN rM and its role in inflammation. First, we demonstrated PMN rM in a mouse model of LPS-induced acute lung inflammation. By single-cell RNA sequencing (scRNA-seq), we demonstrated that reverse migrated (rM-ed) PMNs in blood expressed high level of immuneresponsive gene 1 (Irg1), the encoding gene of cis-aconitate decarboxylase (ACOD1).
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Direct links to NCBI, no account and no request form: the whole study as GSE263953_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1100455 and SRA study SRP501775. Searching any of these in the dataset finder brings you back here.

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