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Spatial transcriptomics reveals distinct tumor microenvironment of murine breast cancer model undergoing treatment with a humanized monoclonal antibody targeting FABP4

GSE264099 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/09/01 Platform GPL24247
Summary
Circulating levels of adipocyte fatty acid binding protein (A-FABP, also known as FABP4) are linked with metabolic dysregulation. Our previous study demonstrated that high serum levels of FABP4 increased the risk of obesity associated breast cancer. The treatment with anti-FABP4 monoclonal anitbody was demonstrated to inhibit mammary tumor growth in a syngeneic mouse model. We hypothesized that spatial transcriptomic analysis would identidy the relationship between tumor cells and tumor-associated stromal cells during the antibody treatment.
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Also filed as BioProject PRJNA1100989 and SRA study SRP502060. Searching any of these in the dataset finder brings you back here.

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