GEO series
Transcriptome analysis of sham-operated, MI-injured and FGF17-treated MI mice hearts (MI)
GSE264234
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2026/04/05
GPL24247
Summary
Fibroblast growth factor (FGF) signal transduction plays essential roles in cardiac repair following myocardial infarction (MI). Among which, FGF17 was demonstrated to regulate epicardial epithelial-mesenchymal transition to provide new vasculature for muscle regeneration during the process of myocardial repair in zebrafish. However, little is known about its function in the mammalian cardiovascular system. This study investigated whether FGF17 signaling exerts cardioprotective effects in ischemic mice hearts, and attempted to elucidate the underlying mechanisms.
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