Amino Acids as a Major Carbon Source for Hepatic Lipogenesis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 × SPD vs 6 × LPDGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Amino acid is a major carbon source for hepatic lipogenesisCell metabolism · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264493_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1102706 and SRA study SRP503028. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8218925 SPD rep1 SPD
- GSM8218926 SPD rep2 SPD
- GSM8218927 SPD rep3 SPD
- GSM8218928 SPD rep4 SPD
- GSM8218929 SPD rep5 SPD
- GSM8218930 SPD rep6 SPD
- GSM8218931 LPD rep1 LPD
- GSM8218932 LPD rep2 LPD
- GSM8218933 LPD rep3 LPD
- GSM8218934 LPD rep4 LPD
- GSM8218935 LPD rep5 LPD
- GSM8218936 LPD rep6 LPD
- GSE297644 Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis 24 samples shares hepatic, carbon
- GSE304736 Hepatic CB1 receptor signaling triggers Gi/oα-mediated lipolysis in lean mice but Gsα-mediated lipogenesis in obese mice 23 samples shares lipogenesis, hepatic
- GSE311156 Technical and biological sources of noise confound multiplexed enhancer AAV screening [dataset3] 797 samples shares source
- GSE294630 CDA HFD mice analysed for hepatic gene expression after treatment with semaglutide 97 samples shares hepatic
- GSE276155 RBBP5 is an epigenetic regulator of mammalian hepatic 12h oscillator [RNA-seq] 96 samples shares hepatic
- GSE248864 Hepatic Glucocorticoid Receptor (GR) drives the diurnal adaptation to Caloric Restriction 90 samples shares hepatic
- GSE268864 Hepatic PKA Mediates the Liver and Pancreatic Alpha-Cell Crosstalk 90 samples shares hepatic
- GSE279388 Inactivation of Atp7b copper transporter in the intestinal epithelial cells is associated with altered lipid processing and cell growth machinery that are independent from hepatic copper accumulation and liver histology severity 76 samples shares hepatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.