CD40 stimulation + dasatinib treatment of chronic lymphocytic leukemia (CLL) cells
RNA-seq (gene expression) · human · 3 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Chronic lymphocytic leukemiaThis series is part of our curated briefing on it.
- Samples
- 3 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- T-cell dysfunction in CLL is mediated through expression of Siglec-10 ligands CD24 and CD52 on CLL cellsBlood advances · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264554_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1103147 and SRA study SRP503327. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 3 more — browse all 3 samples with per-sample file links →
- GSE21029 The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia (CLL) 62 samples same disease briefing · shares cll, lymphocytic, leukemia, chronic
- GSE245432 Treatment of chronic lymphocytic leukemia cells with signaling inhibitors 14 samples same disease briefing · shares lymphocytic, treatment, leukemia, chronic
- GSE313098 Time-series RNA-seq analysis reveals dynamic transcriptional responses and crosstalk in chronic lymphocytic leukaemia (CLL) autologous and monoculture in vitro models 60 samples same disease briefing · shares cll, lymphocytic, chronic
- GSE246521 Chronic Lymphocytic Leukemia in African Ancestry Population is Characterized by Increased Genomic Instability 350 samples same disease briefing · shares lymphocytic, leukemia, chronic
- GSE136634 Clinical and biological implications of target occupancy in chronic lymphocytic leukemia treated with acalabrutinib 124 samples same disease briefing · shares lymphocytic, leukemia, chronic
- GSE267095 The Effect of a Novel Preclinical Agent, SpiD3, on Drug-resistant Chronic Lymphocytic Leukemia 36 samples same disease briefing · shares lymphocytic, leukemia, chronic
- GSE283045 PD-1 expression identifies activated and proliferating chronic lymphocytic leukemia cells and is a potential biomarker that informs response and resistance to BTK inhibitor therapy 35 samples same disease briefing · shares lymphocytic, leukemia, chronic
- GSE233157 Expression Signature of Human Endogenous Retroviruses in Chronic Lymphocytic Leukemia 24 samples same disease briefing · shares lymphocytic, leukemia, chronic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.