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Endothelial IGFBP6 Suppresses Vascular Inflammation and Atherosclerosis

GSE265787 Homo sapiens Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing 9 samples Submitted 2024/05/01 Platform GPL30209
Summary
It has previously been reported that expression levels of insulin-like growth factor binding protein 6 (IGFBP6) are reduced in unstable plaques compared to stable plaques in patients with coronary heart disease (CAD). However, the exact role and mechanism of IGFBP6 in endothelial homeostasis and inhibition of focal atherosclerotic plaque development in vivo remains unclear. Transcripome sequencing and bioinformatics analysis of IGFBP6-overexpressed human umbilical vein endothelial cells (HUVECs) suggest that pathway analysis and differentially expressed mRNA may help clarify the role and potential mechanism of IGFBP6 in the treatment of cardiovascular diseases.
Published in
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis
Su M, Zhao W, Jiang H et al. · Nature cardiovascular research 2025 · PMID 39794479 · doi:10.1038/s44161-024-00591-0
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Also filed as BioProject PRJNA1104204 and SRA study SRP503832. Searching any of these in the dataset finder brings you back here.

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