GEO series
A cardiac fibroblast-enriched micropeptide regulates inflammation
GSE266133
Mus musculus
Expression profiling by high throughput sequencing
35 samples
2025/03/12
GPL30215GPL23479
Summary
Knockdown of IAMP resulted in significant alterations in the transcriptome. Upon cross-analysis of the transcriptomic changes induced by the two siRNAs, we identified 190 genes that were commonly upregulated and 342 genes that were commonly downregulated in both datasets. KEGG enrichment analysis of these differentially expressed genes revealed that IAMP knockdown led to the upregulation of genes associated with inflammation-related pathways, such as the TNF and IL-17 signaling pathways. Collectively, these data suggest that IAMP functions as an anti-inflammatory factor in cardiac fibroblasts.
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