Systems modeling of oncogenic G-protein and oncogenic GPCR signaling reveals unexpected differences in downstream signaling pathway activation [FAKi_experiment]
RNA-seq (gene expression) · human · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Uveal melanomaThis series is part of our curated briefing on it.
- Samples
- 27 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activationNPJ systems biology and applications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267153_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1109866 and SRA study SRP506879. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 27 more — browse all 27 samples with per-sample file links →
- GSE294950 Epigenetic library screen reveals novel targets for uveal melanoma 24 samples same disease briefing
- GSE317536 Matched sampling reveals uncoupled phenotypic plasticity during metastasis formation in uveal melanoma 23 samples same disease briefing
- GSE196624 The role of EHMT2 in Uveal melanoma progression [EHMT2_Inhibitors] 18 samples same disease briefing
- GSE231395 PRAME induces genomic instability in uveal melanoma [RNA-seq] 15 samples same disease briefing
- GSE287090 Exploration of tumor associated macrophages in patients with metastatic uveal melanoma by single cell RNAseq 12 samples same disease briefing
- GSE317502 ATR Is a Critical Dependency Gene Supporting Uveal Melanoma Cell Survival 12 samples same disease briefing
- GSE273527 Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma 9 samples same disease briefing
- GSE233589 BET bromodomain inhibition potentiates ocular melanoma therapy by inducing cell cycle arrest 8 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.