Alterations of Ceramide Synthesis Induce PD-L1 Internalization and Signaling to Regulate Tumor Metastasis and Immunotherapy Response
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × Vehicle vs 4 × PD-L1 vs 4 × Sonidegib vs 4 × ComboGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267312_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1111042 and SRA study SRP507298. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8263769 Vehicle 1 Vehicle
- GSM8263770 Vehicle 2 Vehicle
- GSM8263771 Vehicle 3 Vehicle
- GSM8263772 Vehicle 4 Vehicle
- GSM8263773 PD-L1 1 PD-L1
- GSM8263774 PD-L1 2 PD-L1
- GSM8263775 PD-L1 3 PD-L1
- GSM8263776 PD-L1 4 PD-L1
- GSM8263777 Sonidegib 1 Sonidegib
- GSM8263778 Sonidegib 2 Sonidegib
- GSM8263779 Sonidegib 3 Sonidegib
- GSM8263780 Sonidegib 4 Sonidegib
- GSM8263781 Combo 1 Combo
- GSM8263782 Combo 2 Combo
- GSM8263783 Combo 3 Combo
- GSM8263784 Combo 4 Combo
- GSE333427 IGF2BP1 in 17q-gain cooperates with MYCN to regulate purine biosynthesis and immunotherapy efficacy in neuroblastoma 9 samples shares immunotherapy, synthesis, regulate
- GSE304155 HE4 regulates anticancer immune evasion by upregulating PD-L1 expression on macrophages through the IFN-γR-STAT3 axis [LLC tumors, scRNA-seq] 6 samples shares pd-l1, regulate
- GSE234086 The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy 24 samples shares immunotherapy, regulate
- GSE260816 Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells 46 samples shares pd-l1
- GSE292146 Tractable mouse TNBC models capture the heterogeneous tumor immune microenvironment and adaptation to PD-L1 blockade 38 samples shares pd-l1
- GSE328461 Osteopontin mediates acquired resistance to hypoxia-inducing antiangiogenics and promotes anti-PD-L1 refractoriness in breast cancer models 37 samples shares pd-l1
- GSE324386 Transcriptomic profiling of CRISPR-Cas9 knockout of RAD51D, LIMCH1, and BRD9 in MC38 colorectal cancer cells reveals regulation of PD-L1 expression 29 samples shares pd-l1
- GSE277610 Endothelial PD-L1 brakes CD8+ T cell exhaustion, empowering anti-tumor immunity in non-small cell lung cancer 17 samples shares pd-l1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.