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Role of CB2 in adipose tissue ILC2s

GSE268067 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/16 Platform GPL19057
Summary
Development of type 2 diabetes mellitus (T2DM) is associated low-grade chronic type 2 inflammation and disturbance of glucose homeostasis. Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via production of type 2 cytokines. Here, we demonstrate that CB2, a G-protein coupled receptor (GPCR) and member of endocannabinoid system, is expressed on both visceral adipose tissue (VAT)-derived murine and human ILC2s. Moreover, we utilize a combination of ex vivo and in vivo approaches to explore the functional and therapeutic impacts of CB2 engagement on VAT ILC2s in T2DM model. Our results show CB2 stimulation of ILC2s protects against insulin-resistance onset, ameliorates glucose tolerance, and reverses established insulin-resistance. Our mechanistic studies reveal that the therapeutic effects of CB2 are mediated through activation of AKT, ERK1/2 and CREB pathways on ILC2s. The results reveal that CB2 agonist can serve as candidate for prevention and treatment of T2DM.
Published in
CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus
Shafiei-Jahani P, Yan S, Kazemi MH et al. · Cell reports 2024 · PMID 38963763 · doi:10.1016/j.celrep.2024.114434
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Also filed as BioProject PRJNA1114121 and SRA study SRP509078. Searching any of these in the dataset finder brings you back here.

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