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Gene expresion profile of different clusters of antigen specific CD4+ T cells induced by vaccines containing high doses of MHC-II restricted neoantigens

GSE268300 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/05/28 Platform GPL24247
Summary
CD4+ T cells induced by vaccines containing high doses of mItgb1 SLP were sorted into 3 different clusters based on the expression of CD25, CD200 and CD39. We found that cluster-3 cells (CD4+ CD25- and CD39+) express high levels of GZMB, Ccl5, Lilirb4 and Sema4a. The gene signature of cluster-3 matched those of mice and human Tr1.
Published in
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy
Sultan H, Takeuchi Y, Ward JP et al. · Nature 2024 · PMID 39048822 · doi:10.1038/s41586-024-07752-y
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Also filed as BioProject PRJNA1116135 and SRA study SRP509779. Searching any of these in the dataset finder brings you back here.

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