SCGB2A1 deficiency impairs endometrial stromal cell decidualization by decreasing CDK3-mediated proliferation in patients with recurrent implantation failure
RNA-seq (gene expression) · human · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 5 × T-HESCs, siSCG vs 5 × T-HESCs, siNCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269408_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1121401 and SRA study SRP512511. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8314550 T-HESCs, siSCG1 T-HESCs, siSCG
- GSM8314551 T-HESCs, siSCG2 T-HESCs, siSCG
- GSM8314552 T-HESCs, siSCG3 T-HESCs, siSCG
- GSM8314553 T-HESCs, siSCG4 T-HESCs, siSCG
- GSM8314554 T-HESCs, siSCG5 T-HESCs, siSCG
- GSM8314555 T-HESCs, siNC1 T-HESCs, siNC
- GSM8314556 T-HESCs, siNC2 T-HESCs, siNC
- GSM8314557 T-HESCs, siNC3 T-HESCs, siNC
- GSM8314558 T-HESCs, siNC4 T-HESCs, siNC
- GSM8314559 T-HESCs, siNC5 T-HESCs, siNC
- GSE306127 Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of VDR in the epigenomic network [CUT&Run] 48 samples shares decidualization, endometrial, deficiency
- GSE325553 Comparative transcriptomic profiling of human 3D endometrial stromal organoids under distinct decidualization stimuli 20 samples shares decidualization, endometrial
- GSE294481 Effects of Amino Acid Restriction on Decidualization of Human Endometrial Stromal Cells 12 samples shares decidualization, endometrial
- GSE91077 Global transcriptional profiling confirmed failed decidualization of human Endometrial Stromal Cells (hESCs) obtained from non-pregnant women with a previous pregnancy complicated by severe preeclampsia (sPE). 20 samples shares decidualization, endometrial
- GSE313416 Transient proliferation by reversible YAP- and mitogen-control of the cyclin D1/p27 ratio 63 samples shares proliferation
- GSE299964 Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [RNA-Seq] 50 samples shares proliferation
- GSE265940 Overexpression of extracellular matrix proteins, increased cell death and reduced cell proliferation contribute to the pathophysiology of microphthalmia across in vitro patient-derived models 48 samples shares proliferation
- GSE164893 Post-transcriptional regulation of proliferation and quiescence (mRNAdecay) 48 samples shares proliferation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.