GEO series
TGFBI is upregulated in ectopic endometrial stromal cells and under hypoxic conditions in endometriosis.
GSE269530
Homo sapiens
Expression profiling by high throughput sequencing
20 samples
2024/12/07
GPL24676
Summary
The objective of the study was to compare the transcriptome of the primary eutopic and ectopic endometrial stromal cells isolated from paired eutopic endometrium and peritoneal lesions from women with endometriosis (N = 5) exposed to normoxic (20% O2) or hypoxic (1% O2) conditions for 48 hours. Induced expression of TGFBI was found in ectopic cells and ectopic & eutopic cells exposed to hypoxia at both RNA and protein (secreted to the culture media) levels. TGFBI gene and protein expression ex vivo in euoptic endometrium of women with endometriosis and controls (women without endometriosis) was found to be increased in the proliferative phase of menstrual cycle compared to secretory phase.
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Paper (PMID 39744178) ↗
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