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Samd7 preserves cell identity and enforces the ‘one neuron-one receptor’ rule in vertebrate photoreceptors

GSE269667 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/21 Platform GPL34290
Summary
The exclusive expression of single sensory receptors in individual neurons (the ‘one-neuron-one receptor’ rule) is essential for vision and other sensory systems. Here, we show that the transcriptional corepressor Samd7 enforces this rule in vertebrate red cones and acts in other photoreceptor types to maintain cell identity. In the zebrafish samd7-/- retina, red cones are transformed to hybrid red/UV-sensitive cones, green cones are transfated to blue cones, and the number of rods is greatly reduced. In the mouse Samd7-/- retina, dorsal M-cones are transformed to hybrid M/S-cones—analogous to the transformation of red to red/UV cones that occurs in zebrafish—and rods aberrantly express cone genes including S-opsin. Altogether, Samd7 acts to repress short-wavelength cone gene expression in long-wavelength-sensitive cones, thereby sustaining the mutually exclusive patterns of opsin expression and cone identity required for color vision.
Published in
Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity
Volkov LI, Ogawa Y, Somjee R et al. · Proceedings of the National Academy of Sciences of the United States of America 2024 · PMID 39531499 · doi:10.1073/pnas.2402121121
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Also filed as BioProject PRJNA1123197 and SRA study SRP513596. Searching any of these in the dataset finder brings you back here.

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