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MAIT cells protect against sterile lung injury

GSE270623 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/02/04 Platform GPL34290
Summary
Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, have been recently linked to tissue protection and repair. Their role, especially in sterile lung injury, is unknown. Using single cell RNA sequencing (scRNA-seq), spectral analysis and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and induces an accompanying tissue repair programme, associated with a protective role against bleomycin-induced lung injury. MAIT cells drive the accumulation of type 1 conventional dendritic cells (cDC1), limiting tissue damage in a DNGR-1 dependent manner. Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defence against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways.
Published in
MAIT cells protect against sterile lung injury
Zhang X, Li S, Lason W et al. · Cell reports 2025 · PMID 39918959 · doi:10.1016/j.celrep.2025.115275
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Also filed as BioProject PRJNA1127005 and SRA study SRP515407. Searching any of these in the dataset finder brings you back here.

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