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Effect of elastin insufficiency on gene expression in cultured human aortic smooth muscle cells

GSE270681 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/12 Platform GPL24676
Summary
Defective elastin induces aortic smooth muscle cell hyperproliferation. To elucidate gene expression changes with elastin insufficiency, bulk RNA-seq was performed on cultured human aortic smooth muscle cells treated with siRNA targeting elastin.
Published in
Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization
Saito J, Dave JM, Gallardo-Vara E et al. · Nature cardiovascular research 2026 · PMID 41492020 · doi:10.1038/s44161-025-00762-7
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Also filed as BioProject PRJNA1127986 and SRA study SRP515817. Searching any of these in the dataset finder brings you back here.

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