Tet2-mediated clonal hematopoiesis improves neurological deficits and is associated with inflammation resolution in the subacute phase of stroke
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 × Brain, WT, vs 6 × Brain, KO,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tet2-mediated clonal hematopoiesis modestly improves neurological deficits and is associated with inflammation resolution in the subacute phase of experimental strokeFrontiers in cellular neuroscience · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270710_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1128060 and SRA study SRP516023. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8350467 Brain, WT, 1 Brain, WT,
- GSM8350468 Brain, WT, 2 Brain, WT,
- GSM8350469 Brain, WT, 3 Brain, WT,
- GSM8350470 Brain, WT, 4 Brain, WT,
- GSM8350471 Brain, WT, 5 Brain, WT,
- GSM8350472 Brain, WT, 6 Brain, WT,
- GSM8350473 Brain, KO, 1 Brain, KO,
- GSM8350474 Brain, KO, 2 Brain, KO,
- GSM8350475 Brain, KO, 3 Brain, KO,
- GSM8350476 Brain, KO, 4 Brain, KO,
- GSM8350477 Brain, KO, 5 Brain, KO,
- GSM8350478 Brain, KO, 6 Brain, KO,
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- GSE272266 Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen [scRNA-Seq] 20 samples shares hematopoiesis, clonal
- GSE327454 TET2-mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis [RNA-seq] 19 samples shares hematopoiesis, clonal
- GSE274878 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [RNAseq_mouse] 19 samples shares hematopoiesis, clonal
- GSE274864 Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy [RNA-seq] 17 samples shares hematopoiesis, clonal
- GSE279334 NAD+ - and EVA1-C-dependent reversal of neurological deficits is mediated by differential alternative RNA splicing in tauopathic animal models 16 samples shares neurological, deficits
- GSE266580 Ablation of Id1 Reduces Clonal Hematopoiesis, Genomic Instability and Delays Leukemia in Mice with Tet2 Loss of Function [RNA-seq] 12 samples shares hematopoiesis, clonal
- GSE276811 Fructose feeding on Asxl1-mutant clonal hematopoiesis [single-cell RNA-seq] 12 samples shares hematopoiesis, clonal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.