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Gene expression profile at single-cell level of cardiac cells derived from adult heart following injury

GSE271177 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/09 Platform GPL24247
Summary
Myocardial injury may ultimately lead to adverse ventricular remodeling and development of heart failure (HF), which is a major cause of morbidity and mortality worldwide. Given the slow pace and substantial costs of developing new therapeutics, drug repurposing is an attractive alternative. Studies of many organs, including the heart, highlight the importance of the immune system in modulating injury and repair outcomes. Glatiramer-acetate (GA) is an immunomodulatory drug prescribed for patients with multiple sclerosis. Here we report that short-term GA treatment improves cardiac function and reduces scar area in a mouse model of acute myocardial infarction and a rat model of ischemic HF. We provide mechanistic evidence indicating that in addition to its immunomodulatory functions, GA exerts beneficial pleiotropic effects, including cardiomyocyte protection and enhanced angiogenesis. Overall, these findings highlight the potential repurposing of GA as a future therapy for a myriad of heart diseases.
Published in
Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models
Aviel G, Elkahal J, Umansky KB et al. · Nature cardiovascular research 2024 · PMID 39215106 · doi:10.1038/s44161-024-00524-x
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Direct links to NCBI, no account and no request form: the whole study as GSE271177_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1130408 and SRA study SRP517221. Searching any of these in the dataset finder brings you back here.

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