Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [RNA-seq}
RNA-seq (gene expression) · mouse · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 8 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE326291_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1445073 and SRA study SRP687661. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 36 samples.
How we read this: 8 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9627708 Untreated_EV_1 Untreated_EV
- GSM9627709 Untreated_EV_2 Untreated_EV
- GSM9627710 Untreated_EV_3 Untreated_EV
- GSM9627711 Untreated_EV_4 Untreated_EV
- GSM9627712 Myxothiazol_EV_1 Myxothiazol_EV
- GSM9627713 Myxothiazol_EV_2 Myxothiazol_EV
- GSM9627714 Myxothiazol_EV_3 Myxothiazol_EV
- GSM9627715 Myxothiazol_EV_4 Myxothiazol_EV
- GSM9627716 Untreated_L2hgdh_1 Untreated_L2hgdh
- GSM9627717 Untreated_L2hgdh_2 Untreated_L2hgdh
- GSM9627718 Untreated_L2hgdh_3 Untreated_L2hgdh
- GSM9627719 Untreated_L2hgdh_4 Untreated_L2hgdh
- GSM9627720 Myxothiazol_L2hgdh_1 Myxothiazol_L2hgdh
- GSM9627721 Myxothiazol_L2hgdh_2 Myxothiazol_L2hgdh
- GSM9627722 Myxothiazol_L2hgdh_3 Myxothiazol_L2hgdh
- GSM9627723 Myxothiazol_L2hgdh_4 Myxothiazol_L2hgdh
- GSM9627724 L2HGDH_OE_Kidney_1 L2HGDH_OE_Kidney
- GSM9627725 L2HGDH_OE_Kidney_2 L2HGDH_OE_Kidney
- GSM9627726 L2HGDH_OE_Kidney_3 L2HGDH_OE_Kidney
- GSM9627727 L2HGDH_OE_Kidney_4 L2HGDH_OE_Kidney
- GSM9627728 L2HGDH_OE_Kidney_5 L2HGDH_OE_Kidney
- GSM9627729 WT_Kidney_1 WT_Kidney
- GSM9627730 WT_Kidney_2 WT_Kidney
- GSM9627731 WT_Kidney_3 WT_Kidney
- GSM9627732 WT_Kidney_4 WT_Kidney
- GSM9627733 WT_Kidney_5 WT_Kidney
- GSM9627734 L2HGDH_OE_Liver_1 L2HGDH_OE_Live
- GSM9627735 L2HGDH_OE_Liver_2 L2HGDH_OE_Live
- GSM9627736 L2HGDH_OE_Liver_3 L2HGDH_OE_Live
- GSM9627737 L2HGDH_OE_Liver_4 L2HGDH_OE_Live
- GSM9627738 L2HGDH_OE_Liver_5 L2HGDH_OE_Live
- GSM9627739 WT_Liver_1 WT_Live
- GSM9627740 WT_Liver_2 WT_Live
- GSM9627741 WT_Liver_3 WT_Live
- GSM9627742 WT_Liver_4 WT_Live
- GSM9627743 WT_Liver_5 WT_Live
- GSE273473 Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [ChIP-seq] 14 samples shares l-2-hydroxyglutarate, mitochondrial, physiologic, metabolite
- GSE280699 The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age [RNA-seq] 78 samples shares mitochondrial, rna-seq
- GSE273310 DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq] 64 samples shares mitochondrial, rna-seq
- GSE272476 Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells [RNA-seq] 30 samples shares metabolite, rna-seq
- GSE341280 Systematic identification of age-related microbiome metabolites that impact the brain - mouse brain RNA-seq 28 samples shares metabolite, rna-seq
- GSE312828 Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution. [RNA-Seq] 24 samples shares mitochondrial, rna-seq
- GSE276024 Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells [RNA-seq] 24 samples shares mitochondrial, rna-seq
- GSE225414 Mitochondrial regulation of bone homeostasis via mitochondria transfer [RNA-seq] 18 samples shares mitochondrial, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.