Phospholipase D2 downregulates interleukin-1β secretion from tumor-associated macrophages to suppress bladder cancer progression
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × BBN_bladder, WT, 16w vs 3 × BBN_bladder, PLD2-KO, 16w vs 3 × TAMs, WT, vs 3 × TAMs, PLD2-KO,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Phospholipase D2 downregulates interleukin-1β secretion from tumor-associated macrophages to suppress bladder cancer progressionCancer science · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271595_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1132267 and SRA study SRP518209. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8380220 BBN_bladder, WT, 16w-1 BBN_bladder, WT, 16w
- GSM8380221 BBN_bladder, WT, 16w-2 BBN_bladder, WT, 16w
- GSM8380222 BBN_bladder, WT, 16w-3 BBN_bladder, WT, 16w
- GSM8380223 BBN_bladder, PLD2-KO, 16w-1 BBN_bladder, PLD2-KO, 1…
- GSM8380224 BBN_bladder, PLD2-KO, 16w-2 BBN_bladder, PLD2-KO, 1…
- GSM8380225 BBN_bladder, PLD2-KO, 16w-3 BBN_bladder, PLD2-KO, 1…
- GSM8380226 TAMs, WT, 1 TAMs, WT,
- GSM8380227 TAMs, WT, 2 TAMs, WT,
- GSM8380228 TAMs, WT, 3 TAMs, WT,
- GSM8380229 TAMs, PLD2-KO, 1 TAMs, PLD2-KO,
- GSM8380230 TAMs, PLD2-KO, 2 TAMs, PLD2-KO,
- GSM8380231 TAMs, PLD2-KO, 3 TAMs, PLD2-KO,
- GSE230162 Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancer 24 samples shares tumor-associated, macrophages, suppress
- GSE291140 AMPK suppresses multiple cell death pathways to sustain tumor-associated macrophage proportion and promotes tumor progression 12 samples shares tumor-associated, progression, suppress
- GSE229222 Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers, bulk RNA-seq 12 samples shares tumor-associated, macrophages, suppress
- GSE229223 Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers, single-cell RNA-seq 12 samples shares tumor-associated, macrophages, suppress
- GSE326350 Circ_0005406 Promotes Ovarian Cancer Progression through IL-33-Dependent Recruitment of Tumor-Associated Macrophages 6 samples shares tumor-associated, macrophages, progression
- GSE317011 β-Elemene Enhances the Efficacy of PD-L1 Inhibitor in Lung Cancer by Reprogramming Tumor-Associated Macrophages to M1 Phenotype via Suppressing FLT1/PI3K/AKT Signaling 6 samples shares tumor-associated, macrophages, suppress
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares tumor-associated, macrophages
- GSE249577 Research on the Mechanism of PTEN Mediated tumor-associated macrophages (TAMs) Polarization 46 samples shares tumor-associated, macrophages
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.