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Ddit4 deficiency leads to a defect in AE9a induced leukemia development

GSE272010 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/04 Platform GPL34290
Summary
Our research indicated knock out of DDIT4 markedly suppresses leukemia initiation potential, leukemia maintenance and self-renewal of AE9a leukemia cells in vivo. To better understand the molecular mechanisms underlying the role of DDIT4 in self-renewal of LSC and leukemia initiation, we performed global gene expression profiling by RNA sequencing on AE9a-Ddit4+/+ and AE9a-Ddit4-/- leukemia cells.
Published in
The critical role of DNA damage-inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation
Li Y, Cao Z, Xing H et al. · Molecular oncology 2025 · PMID 40621878 · doi:10.1002/1878-0261.70090
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Also filed as BioProject PRJNA1134614 and SRA study SRP519286. Searching any of these in the dataset finder brings you back here.

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