REV-ERBs agonist SR9009 inhibits liver fibrosis progression in a MASH fibrosis model invivo.
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 × Chow vs 5 × Vehicle vs 5 × SR9009Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting the liver clock improves fibrosis by restoring TGF-β signalingJournal of hepatology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272293_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1136036 and SRA study SRP520010. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 3 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8397925 Chow_1 Chow
- GSM8397926 Vehicle_1 Vehicle
- GSM8397927 SR9009_1 SR9009
- GSM8397928 SR9009_2 SR9009
- GSM8397929 SR9009_3 SR9009
- GSM8397930 Vehicle_2 Vehicle
- GSM8397931 Vehicle_3 Vehicle
- GSM8397932 SR9009_4 SR9009
- GSM8397933 Vehicle_4 Vehicle
- GSM8397934 Vehicle_5 Vehicle
- GSM8397935 SR9009_5 SR9009
- GSM8397936 Chow_2 Chow
- GSM8397937 Chow_3 Chow
- GSM8397938 Chow_4 Chow
- GSM8397939 Chow_5 Chow
- GSE316023 AI digital pathology as a key tool providing in-depth understanding of the progression and regression of MASH and fibrosis in male mouse models 77 samples shares mash, progression, fibrosis
- GSE279351 Liver-specific inactivation of Cideb improves metabolic profiles and ameliorates steatohepatitis and fibrosis in animal models for MASH 45 samples shares mash, fibrosis
- GSE290235 Fibrogenic gene signature as early prediction for the efficacy of pharmacological interventions for MASH-associated fibrosis, part1 32 samples shares mash, fibrosis
- GSE290237 Fibrogenic gene signature as early prediction for the efficacy of pharmacological interventions for MASH-associated fibrosis, part2 32 samples shares mash, fibrosis
- GSE264250 MASH fibrosis mouse model for circadian analyses of HSC 22 samples shares mash, fibrosis
- GSE333534 Targeting KRAS in a TRP53/KRAS mouse and organoid model inhibits Barrett Esophagus to Gastroesophageal Adenocarcinoma progression 20 samples shares progression, inhibits
- GSE261845 Targeting melanoma cell-intrinsic beta2 integrin inhibits ICAM-1-mediated tumor progression 20 samples shares progression, inhibits
- GSE307122 Urinary Clusterin as a Biomarker of Human Kidney Disease Progression and Response to the Endothelin Receptor Antagonist Atrasentan: An Exploratory Analysis from the SONAR Trail 17 samples shares progression, agonist
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.