Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine MalonylationArthritis & rheumatology (Hoboken, N.J.) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272422_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1136849 and SRA study SRP520483. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE330452 Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism 64 samples shares malonylation, lysine
- GSE267616 Angptl7+ chondrocytes and Sparc+ osteoblasts mediated the increased angiogenesis and abnormal remodeling of subchondral bone in the development of knee osteoarthritis 6 samples shares osteoarthritis, chondrocyte
- GSE261400 Skatole attenuates osteoarthritis by protecting chondrocytes and mediating macrophage repolarization through regulating the NFκB/MAPK signaling pathway and metabolic reprogramming 9 samples shares osteoarthritis, chondrocyte
- GSE280863 Loss of SIRT5 accelerates the development of pressure-overload induced heart failure upon dysregulating purine and pyrimidine metabolism 24 samples shares sirt5
- GSE283748 Skatole attenuates osteoarthritis by protecting chondrocytes and mediating macrophage repolarization through regulating the NFκB/MAPK signaling pathway and metabolic reprogramming II 10 samples shares osteoarthritis, chondrocyte
- GSE186985 Role of SIRT5 in Inhibition of Myocardial Hypertrophy 10 samples shares sirt5
- GSE270640 Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes [RNA-seq] 22 samples shares chondrocyte
- GSE305415 Control of lipid metabolism in chondrocytes is critical for skeletal growth 6 samples shares chondrocyte
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.