12-Lipoxygenase Inhibition Suppresses Islet Immune and Inflammatory Responses and Delays Autoimmune Diabetes in Human Gene Replacement Mice.
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × M0 Vehicle vs 4 × M0 VLX vs 4 × M1 Vehicle vs 4 × M1 VLXGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- 12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement micebioRxiv : the preprint server for biology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272687_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1137967 and SRA study SRP521082. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8409273 M0 Vehicle 1 M0 Vehicle
- GSM8409274 M0 Vehicle 2 M0 Vehicle
- GSM8409275 M0 Vehicle 3 M0 Vehicle
- GSM8409276 M0 Vehicle 4 M0 Vehicle
- GSM8409277 M0 VLX 1 M0 VLX
- GSM8409278 M0 VLX 2 M0 VLX
- GSM8409279 M0 VLX 3 M0 VLX
- GSM8409280 M0 VLX 4 M0 VLX
- GSM8409281 M1 Vehicle 1 M1 Vehicle
- GSM8409282 M1 Vehicle 2 M1 Vehicle
- GSM8409283 M1 Vehicle 3 M1 Vehicle
- GSM8409284 M1 Vehicle 4 M1 Vehicle
- GSM8409285 M1 VLX 1 M1 VLX
- GSM8409286 M1 VLX 2 M1 VLX
- GSM8409287 M1 VLX 3 M1 VLX
- GSM8409288 M1 VLX 4 M1 VLX
- GSE325466 Transcriptomics of S3 segment in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism response to type 1 diabetes, SGLT1/2 inhibition or GLP1 receptor agonism 54 samples shares inhibition, diabetes
- GSE309517 Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice. 45 samples shares inhibition, suppresses
- GSE318028 Pharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits 246 samples shares inhibition
- GSE293819 Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance 142 samples shares inhibition
- GSE307181 Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor 96 samples shares inhibition
- GSE314288 Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology 92 samples shares replacement
- GSE235623 MERTK inhibition for the treatment of tissue fibrosis [RNA-seq] 86 samples shares inhibition
- GSE278534 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization 76 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.