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Bulk RNA-seq of castration-resistant tumors from Ptenpc-/- mice reconstituted with either F10fl/fl or F10fl/fl; LysM-Cre+ mice

GSE272967 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/21 Platform GPL30172
Summary
PTEN is one of the most altered tumor suppressor genes in human prostate cancer (PCa). Prostate specific-Pten-deficient mouse models develop prostate cancer eventually progressing to castration-resistant prostate cancer (CRPC), also due to alterations of the tumor immune infiltrate. By using single-cell RNA-seq, we report the identification of a subset of CD84+; CD11b+; Ly6G+; Ly6Clow immunosuppressive neutrophils that secreted the coagulation factor X (FX) into the prostate TME to directly promote PCa growth.
Published in
Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
Calì B, Troiani M, Bressan S et al. · Cancer cell 2024 · PMID 39303726 · doi:10.1016/j.ccell.2024.08.018
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Also filed as BioProject PRJNA1139726 and SRA study SRP521998. Searching any of these in the dataset finder brings you back here.

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