GEO series
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages
GSE273148
Mus musculus
Expression profiling by high throughput sequencing; Other
23 samples
2025/07/25
GPL21103GPL24247
Summary
Poor prognosis colorectal cancer (CRC) is linked to a TGF-β-activated tumor microenvironment that suppresses immune responses. Inhibiting TGF-β signaling promotes T cell infiltration and enhances immune checkpoint blockade effectiveness, highlighting a network of genetic programs that prevent effective immune responses and clonal expansion of T cells, ultimately enabling metastatic growth.
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